CorpusHuman Anatomy

Mnemonics

Anatomy mnemonics

310 memory aids for cranial nerves, carpal bones, branches, layers and more — grouped by body system.

Skeletal System 29

Carpal bones (lateral → medial; proximal row then distal row)

"Some Lovers Try Positions That They Can't Handle" — Scaphoid, Lunate, Triquetrum, Pisiform | Trapezium, Trapezoid, Capitate, Hamate. "Trapezium by the thumb".

Tarsal bones

"Tiger Cubs Need MILC" — Talus, Calcaneus, Navicular, Medial, Intermediate and Lateral cuneiforms, Cuboid.

Cranial bones (8)

"PEST OF 6" — Parietal (2), Ethmoid, Sphenoid, Temporal (2), Occipital, Frontal; the "6" reminds you there are six types.

Facial bones (14)

"Virgil Can Not Make My Pet Zebra Laugh" — Vomer, (inferior nasal) Conchae, Nasal, Maxillae, Mandible, Palatine, Zygomatic, Lacrimal.

Vertebrae by region

"Breakfast at 7, lunch at 12, dinner at 5" — 7 cervical, 12 thoracic, 5 lumbar (then 5 fused sacral and ≈4 coccygeal).

Contents of the foramen ovale

"OVALE" — Otic ganglion (lies just below), V3 (mandibular nerve), Accessory meningeal artery, Lesser petrosal nerve, Emissary vein.

Salter–Harris growth-plate fractures

"SALTR" — I Straight across (Slipped), II Above (metaphysis — most common), III Lower (epiphysis), IV Through (metaphysis + plate + epiphysis), V Rammed (crush, worst prognosis).

Nerves at risk with humeral fractures (proximal → distal)

"ARM": Axillary — surgical neck; Radial — mid-shaft (radial groove); Median — supracondylar. Ulnar — medial epicondyle.

Blasts vs clasts

OsteoBlasts Build bone; osteoClasts Chew (or Cut) bone.

Osteoclast

Cranial bones

"PEST OF 6": Parietal, Ethmoid, Sphenoid, Temporal, Occipital, Frontal.

Skull

Foramina of the greater wing (anterior → posterior)

"Standing Room Only": Superior orbital fissure → foramen Rotundum (V2) → foramen Ovale (V3) → (foramen Spinosum, middle meningeal artery).

Sphenoid bone

Superior orbital fissure contents

"Live Frankly To See Absolutely No Insult": Lacrimal, Frontal, Trochlear, Superior division of III, Abducens, Nasociliary, Inferior division of III.

Sphenoid bone

Seven bones of the orbit

"Many Friendly Zebras Enjoy Lazy Summer Picnics": Maxilla, Frontal, Zygomatic, Ethmoid, Lacrimal, Sphenoid, Palatine.

Bony orbit

Intercostal neurovascular bundle

"VAN" from superior to inferior in the costal groove: Vein, Artery, Nerve.

Ribs

At the sternal angle (T4/5) — "RAT PLAn"

Rib 2 (costal cartilage), Aortic arch begins and ends, Trachea bifurcates (carina), Pulmonary trunk bifurcates, Ligamentum arteriosum, Azygos vein joins the SVC — and the plane divides the superior from the inferior mediastinum.

Sternum

Suprascapular notch

"Army over the bridge, Navy under the bridge": suprascapular artery passes above the transverse scapular ligament, the nerve below.

Scapula

Elbow ossification centres

"CRITOE" (≈1-3-5-7-9-11 years): Capitulum, Radial head, Internal epicondyle, Trochlea, Olecranon, External epicondyle.

Humerus

Nerves in contact with the humerus

"ARM": Axillary (surgical neck), Radial (radial groove), Median (supracondylar region); plus Ulnar (behind the medial epicondyle).

Humerus

Galeazzi vs Monteggia

"GRUM": Galeazzi = Radius fracture (+ distal radioulnar dislocation); Ulna fracture = Monteggia (+ radial head dislocation).

Radius

Carpal bones

"Some Lovers Try Positions That They Can’t Handle" — lateral to medial, proximal row then distal row.

Carpal bones

Trapezium vs trapezoid

"Trapezium is by the thumb"; the trapezoid is next to it, medially.

Trapezium

Pelvis shapes (Caldwell–Moloy)

Gynaecoid (round, ideal for birth, ≈50% of women), Android (heart-shaped, male-type), Anthropoid (long AP oval), Platypelloid (flat, wide transverse).

Bony pelvis

Tarsal bones

"Tiger Cubs Need MILC" — Talus, Calcaneus, Navicular, Medial, Intermediate, Lateral cuneiforms, Cuboid.

Tarsal bones

Six synovial joint types

"Please Help Paul Catch Some Balls": Plane, Hinge, Pivot, Condyloid, Saddle, Ball-and-socket.

Synovial joints

Cruciate ligament attachments

"LAMP": Lateral femoral condyle → ACL; Medial femoral condyle → PCL (named by their tibial attachments: Anterior and Posterior intercondylar areas).

Knee joint

Direction of the ACL

"Hands in pockets": the ACL runs like your hands going into the front pockets — from anterior tibia to the lateral side (lateral femoral condyle).

Anterior cruciate ligament

Structures behind the medial malleolus (anterior → posterior)

"Tom, Dick And Very Nervous Harry": Tibialis posterior, flexor Digitorum longus, posterior tibial Artery, Vein(s), tibial Nerve, flexor Hallucis longus.

Ankle joint

Muscular System 25

Rotator cuff (SITS)

Supraspinatus, Infraspinatus, Teres minor (all on the greater tubercle, superior → inferior facets), Subscapularis (lesser tubercle).

Erector spinae, lateral → medial

"I Love Spaghetti": Iliocostalis, Longissimus, Spinalis.

Pes anserinus (anterior → posterior)

"Say Grace before Tea": Sartorius (femoral nerve), Gracilis (obturator nerve), semiTendinosus (tibial nerve). Three muscles, three compartments, three nerves.

Behind the medial malleolus (tarsal tunnel)

"Tom, Dick And Very Nervous Harry": Tibialis posterior, flexor Digitorum longus, posterior tibial Artery, Vein(s), tibial Nerve, flexor Hallucis longus.

Interossei of the hand

PAD (Palmar interossei ADduct) and DAB (Dorsal interossei ABduct), relative to the axis of the middle finger.

Median-nerve muscles of the hand (LOAF)

Lateral two lumbricals, Opponens pollicis, Abductor pollicis brevis, Flexor pollicis brevis (superficial head). Every other intrinsic hand muscle is supplied by the ulnar nerve.

Branches of the facial nerve (muscles of facial expression)

"Two Zebras Bit My Cookie": Temporal, Zygomatic, Buccal, Marginal mandibular, Cervical.

Tendon reflex roots

"S1–2 buckle my shoe" (ankle jerk), "L3–4 kick the door" (knee jerk), "C5–6 pick up sticks" (biceps and brachioradialis), "C7–8 lay them straight" (triceps).

Which bands shorten?

"HI, I'm shrinking": the H zone and I band shorten, while the A band stays the same ("A is Always the same").

Sarcomere

Lateral → medial

"I Love Spaghetti": Iliocostalis, Longissimus, Spinalis.

Erector spinae

Axillary artery branches

"Screw The Lawyer Save A Patient": Superior thoracic (1st part); Thoraco-acromial and Lateral thoracic (2nd part); Subscapular, Anterior and Posterior circumflex humeral (3rd part).

Pectoralis minor

Long thoracic nerve roots

"C5, 6, 7 — raise your wings to heaven": the long thoracic nerve (C5–C7) prevents scapular winging.

Serratus anterior

Order in the costal groove

VAN from top to bottom: intercostal Vein, Artery, Nerve. The nerve is the least protected by the groove.

Intercostal muscles

SITS

Supraspinatus, Infraspinatus, Teres minor, Subscapularis. The first three ("SIT") insert on the greater tubercle from top to bottom. The last ("S") inserts on the lesser tubercle.

Rotator cuff

Median-nerve muscles of the hand

LOAF: Lateral two lumbricals, Opponens pollicis, Abductor pollicis brevis, Flexor pollicis brevis.

Thenar muscles

Innervation

LOAF: the Lateral two lumbricals are median-supplied, like the thenar muscles. The medial two are ulnar-supplied, like the interossei.

Lumbricals (hand)

Femoral triangle contents (lateral → medial)

NAVeL: femoral Nerve, Artery, Vein, Lymphatics (deep inguinal nodes in the femoral canal). Borders: inguinal ligament, sartorius, adductor longus.

Sartorius

Pes anserinus

"Say Grace before Tea": Sartorius, Gracilis, semiTendinosus, in order from anterior to posterior.

Gracilis

Behind the medial malleolus

"Tom, Dick And Very Nervous Harry": Tibialis posterior, flexor Digitorum longus, Artery, Vein, Nerve (tibial), flexor Hallucis longus, from anterior to posterior.

Tibialis posterior

Medial plantar nerve muscles

LAFF: 1st Lumbrical, Abductor hallucis, Flexor digitorum brevis, Flexor hallucis brevis. Every other plantar intrinsic is lateral plantar.

Plantar intrinsic muscles of the foot

Nervous System 60

Cranial nerve names (I–XII)

"Oh Oh Oh To Touch And Feel Very Good Velvet, Such Heaven" — Olfactory, Optic, Oculomotor, Trochlear, Trigeminal, Abducens, Facial, Vestibulocochlear, Glossopharyngeal, Vagus, (Spinal) accessory, Hypoglossal.

Cranial nerve types (sensory / motor / both)

"Some Say Marry Money But My Brother Says Big Brains Matter More" — I S, II S, III M, IV M, V B, VI M, VII B, VIII S, IX B, X B, XI M, XII M. Parasympathetic fibres travel in III, VII, IX and X ("1973").

Exit of the trigeminal divisions

"Standing Room Only" — V1 through the Superior orbital fissure, V2 through foramen Rotundum, V3 through foramen Ovale.

Brachial plexus

"Randy Travis Drinks Cold Beer" — Roots (C5–T1), Trunks (3), Divisions (6), Cords (3), Branches. The terminal branches are "MARMU": Musculocutaneous, Axillary, Radial, Median, Ulnar.

Tendon reflex roots

"S1, 2 — buckle my shoe (ankle jerk); L3, 4 — kick the door (knee jerk); C5, 6 — pick up sticks (biceps, brachioradialis); C7, 8 — lay them straight (triceps)."

The diaphragm

"C3, 4, 5 keeps the diaphragm alive" — the phrenic nerve. A complete cord injury at or above C3 abolishes spontaneous breathing.

Cerebellar signs

"DANISH" — Dysdiadochokinesia, Ataxia (wide-based gait), Nystagmus, Intention tremor, Slurred (scanning) speech, Hypotonia/past-pointing (dysmetria). The signs are ipsilateral to the lesion.

Autonomic actions

Parasympathetic "SLUDD" plus three decreases: Salivation, Lacrimation, Urination, Digestion, Defecation, with decreased heart rate, pupil size and airway diameter. Male sexual function: "Point and Shoot" — Parasympathetic erection, Sympathetic emission.

Anticholinergic toxidrome

"Hot as a hare, dry as a bone, red as a beet, blind as a bat, mad as a hatter, full as a flask."

Autonomic nervous system

Male sexual response

"Point and Shoot": Parasympathetic erection, Sympathetic emission (with somatic pudendal-mediated ejaculation).

Parasympathetic nervous system

Calcarine map

"Cuneus — Ceiling is the floor": the cuneus (above the sulcus) sees the lower field; the lingual gyrus ("tongue", below) sees the upper field.

Occipital lobe

Limbic functions — the "5 Fs"

Feeding, Fleeing, Fighting, Feeling and sex (Fornication) — plus memory.

Limbic system

Papez circuit

"Hippo Forgot My Aunt's Cat Purring" — Hippocampus → Fornix → Mammillary body → Anterior thalamic nucleus → Cingulate gyrus → Parahippocampal gyrus → back to Hippocampus.

Limbic system

Direct vs indirect

"D1 = Direct = Do (go); D2 = inDirect = Don't." Dopamine excites D1 and inhibits D2, so it says GO through both.

Basal nuclei

Lentiform vs striatum

"Lentiform = Putamen + Globus pallidus (the lens is PG-rated); Striatum = Caudate + Putamen."

Basal nuclei

Geniculate nuclei

"Lateral = Light (vision); Medial = Music (hearing)."

Thalamus

Ventral posterior nuclei

"VPL = Limbs/body; VPM = Mouth/face (and taste — think make-up on the face)."

Thalamus

The "rule of 4" of the brainstem

• 4 midline (medial) structures, each starting with M: Motor pathway (corticospinal), Medial lemniscus, Medial longitudinal fasciculus, Motor nuclei of the cranial nerves that divide evenly into 12 (III, IV, VI, XII).
• 4 lateral structures, each starting with S: Spinocerebellar tracts, Spinothalamic tract, Sensory nucleus of V, Sympathetic pathway.
• 4 cranial nerves in the medulla (IX–XII), 4 in the pons (V–VIII) and 4 above the pons (I–IV; III and IV in the midbrain).
Medial syndromes therefore involve M structures, and lateral syndromes involve S structures.

Brainstem

Deep nuclei (lateral → medial)

"Don't Eat Greasy Food" — Dentate, Emboliform, Globose, Fastigial.

Cerebellum

Cerebellar signs

"DANISH" — Dysdiadochokinesia, Ataxia, Nystagmus, Intention tremor, Slurred/scanning speech, Hypotonia.

Cerebellum

Order of the meninges

"PAD" from the brain outwards — Pia, Arachnoid, Dura (the brain is protected by a PAD).

Meninges

Apertures

"Magendie Median, Luschka Lateral" — one median and two lateral openings.

Fourth ventricle

Spinal-nerve numbers

"Breakfast at 7, lunch at 12, dinner at 5": 7 cervical vertebrae (but 8 nerves), 12 thoracic, 5 lumbar. Then 5 sacral and 1 coccygeal nerves, so 8 + 12 + 5 + 5 + 1 = 31.

Spinal nerves

Trunk landmarks

"T4 at the teat pore, T10 at the belly butTEN, L1 at the IL (inguinal ligament)."

Dermatomes

Reflex roots

"S1, 2 buckle my shoe (ankle jerk); L3, 4 kick the door (knee jerk); C5, 6 pick up sticks (biceps, brachioradialis); C7, 8 lay them straight (triceps)."

Myotomes

Names (I → XII)

"Oh Oh Oh To Touch And Feel Very Good Velvet, Ah Heaven." This gives Olfactory, Optic, Oculomotor, Trochlear, Trigeminal, Abducens, Facial, Vestibulocochlear, Glossopharyngeal, Vagus, Accessory and Hypoglossal.

Cranial nerves (overview)

Sensory / Motor / Both (I → XII)

"Some Say Marry Money, But My Brother Says Big Brains Matter More." This gives S S M M B M B S B B M M.

Cranial nerves (overview)

Superior orbital fissure contents

"Live Frankly To See Absolutely No Insult": Lacrimal, Frontal, Trochlear, Superior division of III, Abducens, Nasociliary, Inferior division of III. The first three pass outside the common tendinous ring.

Cranial nerves (overview)

Meyer's loop

"PITS": Parietal → Inferior quadrant, Temporal → Superior quadrant (contralateral homonymous quadrantanopias).

Optic nerve (CN II)

Extraocular innervation

"LR6 SO4, the rest 3." The lateral rectus is supplied by CN VI, the superior oblique by CN IV, and all the others (including LPS) by CN III.

Oculomotor nerve (CN III)

Superior oblique action

"SO4 — Superior Oblique looks dOwn and in." Superior oblique depresses and intorts: "SIN" (Superiors INtort).

Trochlear nerve (CN IV)

Foramina of V1, V2, V3

"Standing Room Only": Superior orbital fissure, foramen Rotundum, foramen Ovale.

Trigeminal nerve (CN V)

V3 motor targets

"Muscles of mastication + Mylohyoid, Anterior belly of digastric, Tensor tympani, Tensor veli palatini" ("MATT"). V3 supplies the two "tensors".

Trigeminal nerve (CN V)

Terminal branches

"To Zanzibar By Motor Car": Temporal, Zygomatic, Buccal, Marginal mandibular, Cervical.

Facial nerve (CN VII)

Facial nerve functions

"Face, ear, taste, tear": muscles of face, stapedius in the ear, taste from the anterior 2/3 of the tongue, and tear (lacrimal) plus salivary secretion.

Facial nerve (CN VII)

Vagal trunks at the hiatus

"LARP": Left vagus becomes the Anterior trunk, Right vagus becomes the Posterior trunk. This follows the 90° rotation of the stomach during development.

Vagus nerve (CN X)

Cutaneous branches

"Little Girls Take Sweets": Lesser occipital, Great auricular, Transverse cervical, Supraclavicular.

Cervical plexus

Organisation

"Randy Travis Drinks Cold Beer": Roots, Trunks, Divisions, Cords, Branches.

Brachial plexus

Terminal branches

"MARMU", from lateral to medial: Musculocutaneous, Axillary, Radial, Median, Ulnar.

Brachial plexus

Posterior cord branches

"STAR": Subscapulars (upper and lower), Thoracodorsal, Axillary, Radial.

Brachial plexus

Muscles supplied

"BEST": Brachioradialis, Extensors (wrist and digits), Supinator, Triceps.

Radial nerve

Median-supplied hand muscles

"LOAF": Lateral two lumbricals, Opponens pollicis, Abductor pollicis brevis, Flexor pollicis brevis.

Median nerve

Median vs ulnar in the forearm

The median nerve supplies all flexors except 1½. Those 1½ are flexor carpi ulnaris and the medial half of FDP, which are supplied by the ulnar nerve.

Median nerve

Interossei actions

"PAD and DAB": Palmar interossei ADduct, Dorsal interossei ABduct. Both are supplied by the ulnar nerve.

Ulnar nerve

Roots

"C5, 6, 7 — raise your wings to heaven." The roots of the nerve that stops scapular winging.

Long thoracic nerve

Neurovascular bundle

"VAN", from top to bottom: Vein, Artery, Nerve. The nerve is the least protected by the costal groove.

Intercostal nerves

Thoracic splanchnic levels

"5–9, 10–11, 12": the greater (5 to 9), lesser (10 and 11) and least (12) splanchnic nerves get progressively smaller and lower.

Splanchnic nerves

Point and shoot

"Point (erection, Parasympathetic pelvic splanchnics), Shoot (emission, Sympathetic lumbar splanchnics)." Ejaculation itself also needs the somatic pudendal nerve (bulbospongiosus).

Splanchnic nerves

Branches (superior → inferior)

"I, I Get Lunch On Fridays": Iliohypogastric, Ilioinguinal, Genitofemoral, Lateral femoral cutaneous, Obturator, Femoral.

Lumbar plexus

Roots

"2 from 1, 2 from 2, 2 from 3": iliohypogastric and ilioinguinal from L1; genitofemoral (L1–2) and lateral femoral cutaneous (L2–3) from two segments each; obturator and femoral from three segments (L2–4).

Lumbar plexus

Femoral triangle contents (lateral → medial)

"NAVY": Nerve, Artery, Vein, Y-fronts (or the empty space of the femoral canal with its lymphatics).

Femoral nerve

S2, 3, 4

"S2, 3, 4 keeps the pelvic floor up off the floor." These segments supply levator ani and the external sphincters (pudendal) and the parasympathetic pelvic splanchnics for bladder, bowel and erection.

Sacral plexus

Tarsal tunnel contents

"Tom, Dick And Very Nervous Harry": Tibialis posterior, flexor Digitorum longus, posterior tibial Artery, Vein, tibial Nerve, flexor Hallucis longus (from anterior to posterior behind the medial malleolus).

Tibial nerve

Roots

"S2, 3, 4 keeps the pelvic floor (and the sphincters) up off the floor."

Pudendal nerve

Channel sequence

"Sodium in, potassium out": Na⁺ in for the upstroke, K⁺ out for the downstroke.

Action potential

Catecholamine synthesis

"Try Lovely Dark Night Expressos": Tyrosine → L-DOPA → Dopamine → Noradrenaline (norepinephrine) → Epinephrine (adrenaline).

Neurotransmitters

Cardiovascular System 29

Branches of the aortic arch

ABC'S: the Aortic arch gives the Brachiocephalic trunk, the left Common carotid and the left Subclavian artery.

Branches of the external carotid artery

"Some Anatomists Like Freaking Out Poor Medical Students": superior thyroid, ascending pharyngeal, lingual, facial, occipital, posterior auricular, maxillary, superficial temporal.

Branches of the subclavian artery

VIT C & D: vertebral, internal thoracic, thyrocervical trunk, costocervical trunk, dorsal scapular.

Abdominal aorta: vertebral levels

"12 – 1 – 1/2 – 2 – 3 – 4": coeliac trunk T12, superior mesenteric artery L1, renal arteries L1–L2, gonadal arteries L2, inferior mesenteric artery L3, aortic bifurcation L4.

Tributaries of the IVC

"I Like To Rise So High": Iliac (common iliac) veins, Lumbar veins, Testicular/ovarian vein (right), Renal veins, Suprarenal vein (right), Hepatic veins.

Auscultation areas

"All Physicians Take Money". Moving from the upper right sternal border to the apex: Aortic (2nd right intercostal space), Pulmonary (2nd left intercostal space), Tricuspid (4th–5th left intercostal space at the sternal edge), Mitral (apex, 5th left intercostal space, midclavicular line).

Tetralogy of Fallot

PROV: Pulmonary (right ventricular outflow) stenosis, Right ventricular hypertrophy, Overriding aorta, Ventricular septal defect.

Right shift of the O₂–Hb dissociation curve

"CADET, face Right". CO₂, Acid, 2,3-DPG (BPG), Exercise and Temperature all shift the curve to the right, which lowers affinity and makes O₂ unloading easier.

Which side is which

"Try before you buy": blood passes the tricuspid valve (right) before the bicuspid, or mitral, valve (left).

Tricuspid valve

WiLLiaM MaRRoW

WiLLiaM (LBBB): a W shape in V1 and an M shape in V6. MaRRoW (RBBB): an M shape in V1 and a W shape in V6.

Right bundle branch

Arch branches

ABC'S: the Arch gives the Brachiocephalic trunk, the left Common carotid and the left Subclavian.

Aorta

Abdominal levels

"12 – 1 – 1/2 – 2 – 3 – 4": coeliac T12, SMA L1, renals L1–L2, gonadals L2, IMA L3, bifurcation L4.

Aorta

IVC tributaries

"I Like To Rise So High": Iliacs, Lumbars, Testicular (right), Renals, Suprarenal (right), Hepatics.

Inferior vena cava

Branches in order

"Some Anatomists Like Freaking Out Poor Medical Students": Superior thyroid, Ascending pharyngeal, Lingual, Facial, Occipital, Posterior auricular, Maxillary, Superficial temporal.

External carotid artery

Branches

VIT C & D: Vertebral, Internal thoracic, Thyrocervical trunk, Costocervical trunk, Dorsal scapular.

Subclavian artery

Branches

"Screw The Lawyer Save A Patient": Superior thoracic; Thoracoacromial, Lateral thoracic; Subscapular, Anterior and Posterior circumflex humeral. The parts give 1, 2 and 3 branches.

Axillary artery

Branches

"Left Hand Side": Left gastric, (common) Hepatic, Splenic.

Coeliac trunk

Branches

"I Love Going Places In My Very Own Underwear": Iliolumbar, Lateral sacral, Gluteal (superior and inferior), internal Pudendal, Inferior vesical (or vaginal), Middle rectal, Vesical (superior), Obturator, Umbilical (and Uterine).

Internal iliac artery

Femoral triangle contents

NAVY, from lateral to medial: Nerve, Artery, Vein, Y-fronts (the empty femoral canal, containing lymph vessels and Cloquet's node).

Femoral artery

Tarsal tunnel order (front to back)

"Tom, Dick And Very Nervous Harry": Tibialis posterior, flexor Digitorum longus, Artery, Vein, Nerve, flexor Hallucis longus.

Posterior tibial artery

Right shift

"CADET, face Right": CO₂, Acid, 2,3-DPG, Exercise and Temperature shift the curve to the right.

Haemoglobin

Vitamin K-dependent factors

"1972": factors 10, 9, 7, 2, plus proteins C and S.

Coagulation cascade

PT versus aPTT

"PT is a WET game": the PT monitors Warfarin and the Extrinsic pathway. "HIP" for the aPTT: it monitors Heparin and the Intrinsic Pathway.

Coagulation cascade

Which side gets louder

RILE: Right-sided murmurs get louder on Inspiration, Left-sided murmurs on Expiration.

Heart sounds and murmurs

Systolic vs diastolic lesions

"MR. ASS": Mitral Regurgitation and Aortic Stenosis are Systolic. "MS. ARD": Mitral Stenosis and Aortic Regurgitation are Diastolic.

Heart sounds and murmurs

Respiratory System 18

Diaphragm apertures

"I 8 10 Eggs At 12": IVC passes at T8, oEsophagus at T10, Aorta at T12.

Phrenic nerve roots

"C3, 4, 5 keeps the diaphragm alive" — the phrenic nerve is the sole motor supply of each hemidiaphragm.

Right shift of the O2–Hb curve

"CADET, face Right": CO2, Acid (H+), DPG (2,3-BPG), Exercise, Temperature — all lower affinity and favour O2 unloading.

Pulmonary artery at the hilum

"RALS": on the Right the pulmonary artery is Anterior to the main bronchus; on the Left it is Superior. The right upper lobe bronchus arises above the artery (eparterial bronchus).

Surface markings of lungs and pleura

"6–8–10" for the inferior lung border and "8–10–12" for the inferior pleural reflection at the midclavicular line, mid-axillary line and paravertebral line respectively. The difference is the costodiaphragmatic recess.

Nasal meatus drainage

"Sphenoid sits high, tears drain low, everything else goes to the middle": sphenoid sinus → sphenoethmoidal recess; posterior ethmoidal cells → superior meatus; frontal, maxillary, anterior and middle ethmoidal cells → middle meatus; nasolacrimal duct → inferior meatus.

Vocal fold abductor

"PCA Pulls Cords Apart" — posterior cricoarytenoid is the only abductor. All intrinsic laryngeal muscles are supplied by the recurrent laryngeal nerve except cricothyroid (external laryngeal nerve), the "singer's muscle" that tenses the cords.

What drains where

"Sphenoid sits high (spheno-ethmoidal recess), tears drain low (inferior meatus), posterior ethmoids go superior, and everything else goes to the middle."

Nasal conchae and meatuses

Cartilages

Unpaired: "The Cat Eats" (Thyroid, Cricoid, Epiglottis). Paired: "All Cute Cats" (Arytenoid, Corniculate, Cuneiform).

Larynx

Abduct vs adduct

"PCA Pulls Cords Apart" — posterior cricoarytenoid abducts; "Lateral Lets them meet" — lateral cricoarytenoid adducts.

Intrinsic laryngeal muscles

Lobes

"Right has thRee": the right lung has three lobes and two fissures; the left has two lobes and one fissure.

Right lung

Right lung segments

"A Pig Ate Lots of Mice; Super Mice Are Like Pigs" — Apical, Posterior, Anterior (upper); Lateral, Medial (middle); Superior, Medial basal, Anterior basal, Lateral basal, Posterior basal (lower).

Bronchopulmonary segments

RALS

Right: artery Anterior to the bronchus; Left: artery Superior to the bronchus. Phrenic in front, vagus behind.

Hilum and root of the lung

Pleura vs lung borders

Lungs: 6–8–10. Pleura: 8–10–12 (midclavicular, mid-axillary, paravertebral lines).

Pleura

Apertures

"I 8 10 Eggs At 12" — IVC T8, oesophagus T10, aorta T12. (Also: "vena cava has 8 letters, oesophagus 10, aortic hiatus 12".)

Diaphragm

Phrenic nerve

"C3, 4, 5 keeps the diaphragm alive."

Diaphragm

Capacities

A capacity is always the sum of two or more volumes. "FRC = ERV + RV — FRC is what's left in the End Recoil position."

Lung volumes and capacities

Digestive System 21

Retroperitoneal organs: SAD PUCKER

Suprarenal (adrenal) glands · Aorta and IVC · Duodenum (2nd–4th parts) · Pancreas (except the tail) · Ureters · Colon (ascending and descending) · Kidneys · Esophagus (thoracic and most of the abdominal part) · Rectum (middle and lower thirds).

Meckel diverticulum: rule of 2s

Found in about 2% of people · about 2 feet (60 cm) proximal to the ileocaecal valve · about 2 inches (5 cm) long · 2 types of ectopic mucosa (gastric and pancreatic) · usually presents before age 2 · about 2:1 male predominance. It is a true diverticulum on the antimesenteric border.

Causes of acute pancreatitis: I GET SMASHED

Idiopathic · Gallstones · Ethanol · Trauma · Steroids · Mumps (and other viruses) · Autoimmune · Scorpion venom · Hypercalcaemia / Hypertriglyceridaemia · ERCP · Drugs (e.g. azathioprine, valproate, thiazides).

Gallstone risk factors: the 5 Fs

Female · Fat (obese) · Fertile (pregnancy, oestrogens) · Forty (age over 40) · Fair. It is a crude but memorable summary of the risk factors for cholesterol stones.

Facial nerve branches in the parotid gland

"To Zanzibar By Motor Car": Temporal · Zygomatic · Buccal · Marginal mandibular · Cervical.

Dental formula (per quadrant)

Permanent: 2-1-2-3 (incisors, canine, premolars, molars) × 4 = 32. Deciduous: 2-1-0-2 × 4 = 20, with no premolars in the deciduous set.

Unpaired gut arteries: 12-1-3

Coeliac trunk at T12 (foregut) · superior mesenteric artery at L1 (midgut) · inferior mesenteric artery at L3 (hindgut). Each supplies one embryological gut segment and matches a site of referred pain: epigastric, umbilical and hypogastric.

Inguinal hernias: MDs don't LIe

Medial to the inferior epigastric vessels = Direct; Lateral = Indirect.

Every "-glossus" is XII except one

Genioglossus, hyoglossus and styloglossus are all hypoglossal. Palatoglossus is a palatal muscle and, like the other palatal muscles except tensor veli palatini, is supplied by the vagus.

Tongue

Dental formula

Permanent 2-1-2-3, deciduous 2-1-0-2 per quadrant, multiplied by 4 for the whole mouth (32 and 20).

Tooth

Facial nerve branches

"To Zanzibar By Motor Car": Temporal, Zygomatic, Buccal, Marginal mandibular, Cervical.

Parotid gland

Meckel: rule of 2s

2% · 2 feet from the ileocaecal valve · 2 inches long · 2 ectopic tissues · presents before age 2 · about 2:1 male.

Ileum

Identifying colon: THE colon

Taeniae coli · Haustra · Epiploic (omental) appendices. None of them are found on the small bowel or the rectum.

Large intestine

Above vs below

Above the line it is all "Internal": Internal haemorrhoids, Insensate (visceral), drained to the Internal iliac and Inferior mesenteric nodes. Below the line the rules are reversed: External, Excruciating, and drained to the groin (superficial inguinal nodes).

Pectinate line

Portal triad in the hepatoduodenal ligament

"DAVe": the bile Duct lies anterior and to the right, the hepatic Artery anterior and to the left, and the portal Vein posterior to both.

Liver

Gallstone risk: the 5 Fs

Female, Fat, Fertile, Forty, Fair.

Gallbladder

Causes of acute pancreatitis: I GET SMASHED

Idiopathic, Gallstones, Ethanol, Trauma, Steroids, Mumps, Autoimmune, Scorpion venom, Hypercalcaemia/Hypertriglyceridaemia, ERCP, Drugs.

Pancreas

Retroperitoneal organs: SAD PUCKER

Suprarenals, Aorta/IVC, Duodenum (2–4), Pancreas (except tail), Ureters, Colon (ascending/descending), Kidneys, Esophagus, Rectum (lower two-thirds).

Peritoneum

Boundaries of the omental foramen

Front: the "portal triad" (hepatoduodenal ligament). Back: the "big vein" (IVC). Roof: the caudate lobe. Floor: the duodenum (1st part).

Omental bursa (lesser sac)

SAD PUCKER

Suprarenal glands · Aorta/IVC · Duodenum (2nd–4th parts) · Pancreas (except tail) · Ureters · Colon (ascending, descending) · Kidneys · Esophagus · Rectum (lower two-thirds).

Retroperitoneal space

Urinary System 16

Hilum of the kidney, anterior → posterior

VAP — Vein, Artery, Pelvis (renal vein most anterior, renal pelvis/ureter most posterior).

Ureter and its crossings

Water under the bridge — the ureter (water) passes under the uterine artery in females and under the ductus (vas) deferens in males. Risk to the ureter when ligating the uterine artery at hysterectomy.

Functions of the kidney

A WET BED — Acid–base balance, Water balance, Erythropoietin, Toxin and waste removal, Blood pressure (renin), Electrolytes, vitamin D activation.

Indications for urgent dialysis

AEIOU — Acidosis (severe metabolic), Electrolytes (refractory hyperkalaemia), Intoxication with dialysable drugs (SLIME: Salicylates, Lithium, Isopropanol/methanol, Metformin, Ethylene glycol), Overload of fluid (refractory pulmonary oedema), Uraemia (pericarditis, encephalopathy, bleeding).

Parts of the male urethra, proximal → distal

PMS — Prostatic (widest, most dilatable), Membranous (shortest; passes through the external sphincter; injured in pelvic fractures), Spongy/penile (longest; injured in straddle injuries).

Causes of renal papillary necrosis

POSTCARDS — Pyelonephritis, Obstruction, Sickle cell disease, Tuberculosis, Cirrhosis, Analgesics (NSAIDs), Renal vein thrombosis, Diabetes mellitus, Systemic vasculitis.

Micturition: autonomic roles

Parasympathetic = Pee (S2–S4 pelvic splanchnics, M3 → detrusor contracts). Sympathetic = Storage (T11–L2 hypogastric, β3 relaxes detrusor, α1 closes the bladder neck). "S2, 3, 4 keeps the pee off the floor" — the pudendal nerve to the external sphincter.

Hilum order

VAP — Vein, Artery, Pelvis from anterior to posterior.

Kidney

Order of the tubule

"Please Let Dr Come" — PCT, Loop of Henle, DCT, Collecting duct.

Nephron

Angiotensin II actions

"ATII is VAST" — Vasoconstriction, Aldosterone release, Sodium (PCT) and water retention with thirst and ADH, Tightens the efferent arteriole (maintains GFR).

Juxtaglomerular cells

Water under the bridge

The ureter (water) passes beneath the uterine artery or ductus deferens (the bridge).

Ureter

PMS

Prostatic — Membranous — Spongy (proximal → distal).

Urethra

Na⁺ reabsorption by segment

65–25–5–3: PCT ≈65%, loop ≈25%, DCT ≈5%, collecting duct ≈3%.

Tubular reabsorption

Pee vs storage

Parasympathetic = Pee; Sympathetic = Storage; "S2, 3, 4 keeps the pee off the floor."

Micturition reflex

Reproductive System 12

Path of sperm

SEVEN UP: Seminiferous tubules → Epididymis → Vas (ductus) deferens → Ejaculatory duct → (Nothing) → Urethra → Penis.

Autonomic control of the male sexual response

Point, Squeeze and Shoot: Parasympathetic → erection (Point); Sympathetic → emission (Squeeze); Somatic (pudendal) → ejaculation (Shoot).

Water under the bridge

The ureter passes under the uterine artery (≈2 cm lateral to the cervix) in women and under the ductus deferens in men — a classic site of ureteric injury in hysterectomy.

Parts of the uterine tube (lateral → medial)

I Am In: Infundibulum (fimbriae) → Ampulla (fertilisation, ectopic) → Isthmus (ligation) → Intramural (uterine) part.

Contents of the spermatic cord — rule of threes

3 arteries (testicular, cremasteric, artery to ductus deferens), 3 veins (pampiniform plexus, cremasteric vein, vein of ductus), 3 nerves (genital branch of genitofemoral, sympathetic testicular plexus; ilioinguinal runs alongside, outside the cord), 3 other (ductus deferens, lymphatics, processus vaginalis remnant). 3 coverings: external spermatic fascia, cremasteric muscle and fascia, internal spermatic fascia.

Prostate zones

Peripheral = Palpable and Prostate cancer (≈70 %); Transition = Too big (BPH); Central = surrounds the ejaculatory Channels.

Causes of postpartum haemorrhage

4 Ts: Tone (uterine atony — commonest), Trauma (tears), Tissue (retained placenta), Thrombin (coagulopathy).

Rule of threes

3 arteries, 3 veins, 3 nerves, 3 others and 3 coverings.

Spermatic cord

Zones

Peripheral = Palpable, Prostate cancer; Transition = Too big (BPH).

Prostate

Factors in labour

3 Ps: Powers (contractions and maternal effort), Passenger (fetal size, presentation, position), Passage (bony pelvis and soft tissues).

Parturition (labour and birth)

Endocrine System 14

Anterior pituitary hormones

FLAT PiG: FSH, LH, ACTH, TSH, Prolactin, (i), GH. The B-FLAT hormones (FSH, LH, ACTH, TSH) come from Basophils; GH and prolactin come from acidophils.

Adrenal cortex zones

GFR from outside in — zona Glomerulosa, Fasciculata, Reticularis — make salt, sugar, sex (aldosterone, cortisol, androgens): "the deeper you go, the sweeter it gets".

Order of hormone loss in a compressive pituitary lesion

Go Look For The Adenoma Please: GH, LH, FSH, TSH, ACTH, Prolactin (prolactin is preserved or rises because the stalk effect removes dopamine inhibition).

Second messengers

cAMP (Gs): FLAT ChAMP — FSH, LH, ACTH, TSH, CRH, hCG, ADH (V2), MSH, PTH (+ calcitonin, GHRH, glucagon). IP₃ (Gq): GOAT HAG — GnRH, Oxytocin, ADH (V1), TRH, Histamine (H1), Angiotensin II, Gastrin. JAK–STAT: PIGGlET — Prolactin, Immunomodulators (cytokines), GH, G-CSF, Leptin, Erythropoietin, Thrombopoietin.

Hyperparathyroidism (hypercalcaemia)

Stones, bones, abdominal groans, thrones and psychiatric overtones — renal calculi, bone pain/fractures, abdominal pain/constipation/pancreatitis, polyuria, depression/confusion.

Phaeochromocytoma

5 Ps: Pressure (hypertension), Pain (headache), Perspiration, Palpitations, Pallor. Block α before β.

MEN syndromes

MEN1 = 3 Ps (Pituitary, Parathyroid, Pancreas). MEN2A = 2 Ps + 1 M (Parathyroid, Phaeochromocytoma, Medullary thyroid carcinoma). MEN2B = 1 P + 2 Ms (Phaeochromocytoma, Medullary carcinoma, Marfanoid habitus/Mucosal neuromas).

Functions of the hypothalamus

TAN HATS: Thirst and water balance, Adenohypophysis control, Neurohypophysis release, Hunger and satiety, Autonomic regulation, Temperature, Sexual behaviour (and circadian rhythm).

Hypothalamic functions

TAN HATS — Thirst, Adenohypophysis, Neurohypophysis, Hunger, Autonomic, Temperature, Sexual behaviour.

Hypothalamus

Anterior pituitary hormones

FLAT PiG — FSH, LH, ACTH, TSH, Prolactin, GH.

Pituitary gland

Synthesis steps

Trap, Oxidise, Organify, Couple, Store, Release, Recycle — NIS, TPO, TPO, TPO, colloid, proteolysis, deiodinase.

Thyroid follicle

Zones and products

GFR — salt, sugar, sex: Glomerulosa → aldosterone; Fasciculata → cortisol; Reticularis → androgens.

Adrenal cortex

Actions of thyroid hormone — the 4 Bs

Brain maturation, Bone growth, β-adrenergic effects (heart rate, contractility), Basal metabolic rate ↑.

Thyroxine (T4)

PTH in the kidney

PTH = Phosphate Trashing Hormone: it dumps phosphate in the proximal tubule while saving calcium distally.

Parathyroid hormone (PTH)

Lymphatic & Immune System 26

Spleen — "1, 3, 5, 7, 9, 11"

Spleen measures ≈ 1 × 3 × 5 inches, weighs ≈ 7 oz (≈ 150–200 g) and lies deep to ribs 9–11 on the left.

Leukocyte differential — "Never Let Monkeys Eat Bananas"

In order of abundance: Neutrophils (≈ 60%) > Lymphocytes (≈ 30%) > Monocytes (≈ 6%) > Eosinophils (≈ 3%) > Basophils (< 1%) — roughly "60, 30, 6, 3, 1".

Hypersensitivity types — "ACID"

Type I Anaphylactic/allergic (IgE, minutes); Type II Cytotoxic (IgG/IgM against cell-bound antigen); Type III Immune-complex; Type IV Delayed (T-cell, 48–72 h).

Immunoglobulin classes — "GAMED"

G crosses the placenta (Gestation) and dominates secondary responses; A guards mucosae (Airways, gut) as a secretory dimer; M is the Mammoth pentamer, Made first; E Elicits allergy and fights helminths via mast cells; D is on naive B cells with IgM (Don't know much else).

Cytokines — "Hot T-bone stEAK"

IL-1 = hot (fever); IL-2 = stimulates T cells; IL-3 = stimulates bone marrow; IL-4 = IgE; IL-5 = IgA (and eosinophils); IL-6 = aKute-phase proteins (CRP).

MHC "rule of 8"

MHC I × CD8 = 8; MHC II × CD4 = 8. Class I (all nucleated cells) presents to CD8 cytotoxic T cells; class II (antigen-presenting cells) presents to CD4 helper T cells.

Encapsulated organisms in asplenia — "SHiN"

Streptococcus pneumoniae, Haemophilus influenzae type b, Neisseria meningitidis — the classic killers after splenectomy (also Salmonella, Klebsiella, group B streptococcus).

DiGeorge syndrome — "CATCH-22"

Cardiac defects, Abnormal facies, Thymic hypoplasia (T-cell deficiency), Cleft palate, Hypocalcaemia (hypoparathyroidism) — deletion on chromosome 22 (22q11.2).

Position in the posterior mediastinum

"The duck between two gooses" — the thoracic duct lies between the az-ygos vein and the a-orta.

Thoracic duct

Superficial collar (posterior → anterior)

"Old Rats Prefer Soft Sugar" — Occipital, Retroauricular, Parotid, Submandibular, Submental.

Cervical lymph nodes

Drainage order — "three feed one, one feeds the apex"

The three peripheral groups — anterior (pectoral), posterior (subscapular) and lateral (humeral) — drain to the central group, which drains to the apical group; the apical nodes form the subclavian trunk. Levels I → II → III follow the same order relative to pectoralis minor.

Axillary lymph nodes

Order of selection

"Cortex before Medulla, + before −": positive selection in the cortex (can you see self-MHC at all?), negative selection in the medulla (do you react too strongly to self?).

Thymus

Sites of fetal haematopoiesis — "Young Liver Synthesises Blood"

Yolk sac (from week 3) → Liver (main fetal site, from ≈ week 6) → Spleen (minor) → Bone marrow (dominant from the third trimester and after birth).

Haematopoiesis

1, 3, 5, 7, 9, 11

≈ 1 inch thick, 3 inches wide, 5 inches long, weighs ≈ 7 oz, lies between ribs 9 and 11.

Spleen

Abundance — "Never Let Monkeys Eat Bananas"

Neutrophils > Lymphocytes > Monocytes > Eosinophils > Basophils (≈ 60 : 30 : 6 : 3 : 1 %).

Leukocytes (white blood cells)

Granulocytes — "BEN"

Basophils, Eosinophils, Neutrophils are the granulocytes; monocytes and lymphocytes are agranulocytes.

Leukocytes (white blood cells)

Myeloma — "CRAB"

HyperCalcaemia, Renal failure, Anaemia, Bone lesions.

Plasma cell

Th1 vs Th2

Th1 fights the 1-celled (intracellular microbes) with IFN-γ and macrophages; Th2 fights the 2-big (worms) with IL-4, IL-5 and IL-13 — and causes allergy.

Helper T cell (CD4⁺)

"GAMED"

G — crosses the placenta, dominates secondary responses; A — mucosal dimer (tears, saliva, milk); M — Mammoth pentamer, Made first; E — allErgy and worms (mast cells); D — on naive B cells with IgM.

Antibody (immunoglobulin)

Complement fragments

C3b binds bacteria (opsonin); C3a, C4a, C5a cause anaphylaxis-like effects (anaphylatoxins); C5a = chemotaxis; C5b–9 = MAC; deficiency of C5–C9 = recurrent Neisseria ("N**ine").

Complement system

Which HLA genes?

Class I has one letter (A, B, C); class II has two letters (DP, DQ, DR).

MHC molecules (HLA)

"Hot T-bone stEAK"

IL-1 hot (fever), IL-2 T cells, IL-3 bone marrow, IL-4 IgE, IL-5 IgA and eosinophils, IL-6 aKute-phase proteins. Bonus: IL-8 "clean up on aisle 8" — neutrophil recruitment; IL-10 calms things down; IL-12 makes Th1.

Cytokines

Active vs passive

Active — you make it (slow, lasting, memory). Passive — you take it (fast, short, no memory).

Adaptive immunity

Cardinal signs

Rubor, calor, tumor, dolor — and functio laesa: red, hot, swollen, painful and not working.

Inflammation

"ACID"

Type I — Anaphylactic/allergic (IgE); Type II — Cytotoxic (antibody against cells); Type III — Immune complex; Type IV — Delayed (T cells). Types I–III are antibody-mediated; type IV is cell-mediated — the "4th T": T cells.

Hypersensitivity reactions

Integumentary System 10

Epidermal strata, superficial → deep

"Come, Let's Get Sun Burned" — stratum Corneum, Lucidum (thick skin only), Granulosum, Spinosum, Basale.

Melanoma warning signs

ABCDE — Asymmetry, Border irregularity, Colour variation, Diameter >6 mm, Evolving (changing size, shape, colour, or new symptoms such as bleeding or itch).

Rule of nines (adult)

Head 9, each arm 9, front of trunk 18 (2 × 9), back of trunk 18, each leg 18, perineum 1 = 100%.

Cutaneous mechanoreceptors

"Meissner = Moving touch, Merkel = Maintained pressure, Pacinian = Pulsing vibration, Ruffini = stRetch." Meissner and Pacinian are rapidly adapting; Merkel and Ruffini are slowly adapting.

Hair growth cycle

Anagen = Active growth (years), Catagen = Collapse/regression (weeks), Telogen = Time-out/resting (months), then eXogen = eXit (shedding).

Sebaceous vs sweat secretion

Sebaceous = Self-destructive (holocrine — whole cell becomes secretion); eccrine = Exocytosis (merocrine).

Strata, surface → deep

"Come, Let's Get Sun Burned" — Corneum, Lucidum, Granulosum, Spinosum, Basale.

Epidermis

Merkel

Merkel = Maintained pressure (slowly adapting) — and the finest map of shapes.

Merkel cell

Hair cycle

Anagen = Active; Catagen = Collapse; Telogen = Time-out; eXogen = eXit.

Hair follicle

Holocrine

Sebaceous = Self-destructive: the whole cell (holo-) becomes the secretion.

Sebaceous glands

Special Senses 25

Extraocular muscle innervation — LR6SO4R3

Lateral Rectus — CN 6 (abducens); Superior Oblique — CN 4 (trochlear); the Rest — CN 3 (oculomotor: superior, inferior and medial rectus, inferior oblique, and levator palpebrae superioris).

Actions of SR, IR, SO, IO — "RAD SIN"

Recti ADduct (superior and inferior rectus), Superiors INtort (superior rectus and superior oblique). By exclusion the obliques abduct and the inferiors extort. Test vertical recti in abduction and obliques in adduction ("look in, then up/down for obliques").

Ten layers of the retina (outer → inner)

"Really Patient Ophthalmologists Often Observe Inner Images Giving New Insight": RPE, Photoreceptor layer, Outer limiting membrane, Outer nuclear, Outer plexiform, Inner nuclear, Inner plexiform, Ganglion cell layer, Nerve fibre layer, Inner limiting membrane.

Auditory pathway — "E COLI MA"

Eighth nerve → Cochlear nuclei → superior Olivary complex → Lateral lemniscus → Inferior colliculus → Medial geniculate nucleus → Auditory cortex (transverse temporal gyri).

Bones of the orbit

"My Zany Sister Finds Excellent Lemon Pies": Maxilla, Zygomatic, Sphenoid, Frontal, Ethmoid, Lacrimal, Palatine.

Caloric testing — COWS

Cold Opposite, Warm Same: the fast phase of nystagmus beats away from a cold-irrigated ear and towards a warm-irrigated ear (in a conscious patient with an intact brainstem).

Ossicles lateral → medial

"Many Infants Scream": Malleus (hammer) → Incus (anvil) → Stapes (stirrup).

Taste nerves — "7, 9, 10"

Anterior two-thirds of the tongue → VII (chorda tympani); posterior third including the circumvallate papillae → IX; epiglottis and pharynx → X. All converge on the nucleus of the solitary tract.

Bones of the orbit

"My Zany Sister Finds Excellent Lemon Pies" — Maxilla, Zygomatic, Sphenoid, Frontal, Ethmoid, Lacrimal, Palatine.

Orbit

Superior orbital fissure contents

"Lazy French Tarts Sit Naked In Anticipation" — Lacrimal, Frontal, Trochlear (above the ring); Superior division of III, Nasociliary, Inferior division of III, Abducens (through the ring).

Orbit

Layers (outer → inner)

"Really Patient Ophthalmologists Often Observe Inner Images Giving New Insight" — RPE, Photoreceptors, OLM, ONL, OPL, INL, IPL, GCL, NFL, ILM.

Retina

Light turns the photoreceptor OFF

"Light → less cGMP → channels close → hyperpolarise → less glutamate." Photoreceptors are the only major sensory receptors that hyperpolarise to their stimulus.

Phototransduction

LGN layers — "See I? I see. See I?"

Layers 1–6 receive Contralateral, Ipsilateral, Ipsilateral, Contralateral, Ipsilateral, Contralateral eye input (C-I-I-C-I-C).

Visual pathway

Meyer loop

"PITS" — Parietal = Inferior quadrant, Temporal = Superior quadrant (contralateral, homonymous).

Visual pathway

Argyll Robertson pupil

"ARP — Accommodation Reflex Present, Pupillary reflex absent" (accommodates but does not react).

Pupillary light reflex

Internal acoustic meatus

"Seven-Up, Coke down": facial nerve (VII) anterosuperior, cochlear nerve anteroinferior.

Inner ear (labyrinth)

Canal pairs

"LARP and RALP" — Left Anterior with Right Posterior; Right Anterior with Left Posterior; the lateral canals pair with each other.

Semicircular canals

E COLI MA

Eighth nerve → Cochlear nuclei → superior Olive → Lateral lemniscus → Inferior colliculus → Medial geniculate → Auditory cortex.

Auditory pathway

Thalamus bypass

"Smell skips the thalamus": every other sense relays in the thalamus before reaching its primary cortex; olfaction goes straight to piriform cortex and reaches the thalamus (mediodorsal nucleus) only secondarily.

Olfactory pathway

Which papillae taste?

"Filiform = Feel only" — all others (fungiform, foliate, circumvallate) have taste buds.

Lingual papillae

7, 9, 10 → NTS → VPM → insula

"Taste goes Solo (solitary tract), VIP (VPM), then In (insula)."

Gustatory pathway

Cells & Tissues 25

Collagen types

Be So Totally Cool, Read Books — Type I: Bone, Skin, Tendon (≈90 % of body collagen); Type II: Cartilage (and vitreous, nucleus pulposus); Type III: Reticulin (blood vessels, granulation tissue, lymphoid stroma); Type IV: Basement membrane.

Phases of mitosis

PPMAT — "Please Pee on the MAT": Prophase, Prometaphase, Metaphase, Anaphase, Telophase (then cytokinesis).

Stop codons

U Are Away · U Are Gone · U Go Away — UAA, UAG, UGA. Start codon: AUG (methionine).

Microtubule motors

Kinesin kicks it out, dynein drags it in — kinesin moves cargo toward the plus end (anterograde, cell periphery/axon terminal); dynein moves toward the minus end (retrograde, centrosome/cell body).

Elastic cartilage

The 3 Es — Ear (auricle and external acoustic meatus), Epiglottis, Eustachian (auditory) tube.

G-protein-coupled receptors

Gq: "HAVe 1 M&M" — H1, α1, V1, M1, M3. Gi: "MAD 2s" — M2, α2, D2. Most others (β1–3, D1, H2, V2) are Gs.

Pathways in both cytosol and mitochondria

"HUGs take two" — Haem synthesis, Urea cycle and Gluconeogenesis use both compartments.

Cytoplasm and cytosol

Bacterial ribosome inhibitors

"Buy AT 30, CCEL (sell) at 50" — Aminoglycosides, Tetracyclines (30S); Chloramphenicol, Clindamycin, Erythromycin, Linezolid (50S).

Ribosome

Coat proteins

COPII goes forward (ER → Golgi, anterograde); COP I goes back (Golgi → ER, retrograde); clathrin carries cargo from the trans-Golgi to endosomes/lysosomes and from the plasma membrane inward.

Golgi apparatus

Niemann–Pick

"No man picks (his nose) with his sphinger" — sphingomyelinase deficiency.

Lysosome

Hunter vs Hurler

"Hunters see clearly and aim for the X" — Hunter syndrome is X-linked with no corneal clouding; Hurler has corneal clouding.

Lysosome

Acrocentric chromosomes (Robertsonian translocations)

13, 14, 15, 21, 22 — "the five acrocentrics". Their short arms carry the rRNA genes.

Chromatin and chromosomes

Which repair for which lesion

UV → NER (XP = "Xtremely Photosensitive"); replication mismatch → MMR (Lynch); double-strand break → HR (BRCA) or NHEJ; single base → BER.

DNA repair

Pump stoichiometry

"Pump 3 out, 2 in" — per ATP the Na⁺/K⁺-ATPase expels 3 Na⁺ and takes up 2 K⁺; the net loss of one positive charge per cycle makes it electrogenic.

Membrane transport

Receptor G-protein coupling

Gq: "HAVe 1 M&M" (H1, α1, V1, M1, M3). Gi: "MAD 2s" (M2, α2, D2). Gs: β1, β2, β3, D1, H2, V2.

Cell signalling and receptors

Motor direction

Kinesin kicks it out (+), dynein drags it in (−).

Cytoskeleton

Order of the junctional complex (apical → basal)

"Tight, Adhere, Desmo" — zonula occludens, zonula adherens, macula adherens; then hemidesmosomes at the base. Gap junctions are scattered along the lateral membrane.

Cell junctions

Cell cycle order

"Go Sally Go! Make Children" — G1, S, G2, Mitosis, Cytokinesis.

Cell cycle

Phases

"I Picked My Apples Today" — Interphase, Prophase (+ Prometaphase), Metaphase, Anaphase, Telophase. Metaphase = Middle; Anaphase = Apart; Telophase = Two nuclei.

Mitosis and cytokinesis

Prophase I substages

"Lazy Zebras Prefer Dozing Daily" — Leptotene, Zygotene, Pachytene, Diplotene, Diakinesis.

Meiosis

Secretion modes

Holocrine = the wHOLE cell; Apocrine = the APex is lost; Merocrine = MERE exocytosis.

Glandular epithelium

Collagen types

"Be So Totally Cool, Read Books" — I: Bone, Skin, Tendon; II: Cartilage; III: Reticulin; IV: Basement membrane.

Extracellular matrix

Collagen synthesis — vitamin C step

Hydroxylation in the RER needs vitamin C; cross-linking outside the cell needs copper.

Extracellular matrix

Locations

The 3 Es: Ear (auricle, external meatus), Epiglottis, Eustachian (auditory) tube.

Elastic cartilage